Toluca Lake is a neighborhood in the city of Los Angeles located in the San Fernando Valley region of Los Angeles County, California, 12 miles (19 km) northwest of Downtown. The name is also given to a private natural lake fed by the Los Angeles River and maintained by neighboring property owners.

The history of Toluca Lake can be traced to the days of the Tongva Indians, followed by Spanish colonization and Mexican independence. Toluca Lake was part of the early rancho system. The original Toluca Lake was divided, with the neighborhood being known as Forman Toluca Ranch. In 1923, investors bought and developed the land as "Toluca Lake Park".

The neighborhood has had notable residents. Ronald and Nancy Reagan held their wedding reception in Toluca Lake. Comedian Bob Hope was a longtime resident of Toluca Lake. More recently, it has been the home of entertainers such as Miley Cyrus, Viola Davis, Steve Carell, and Melissa McCarthy.